The finale for Grey’s Anatomy Season 22 has come and gone, and with it, both Owen Hunt (Kevin McKidd) and Teddy Altman (Kim Raver) have also left the building at Grey Sloan Memorial Hospital … possibly forever.
While their fates were definitively laid out in Thursday’s (May 7) closer, there were quite a few cliffhangers for the other characters in the surgical crew.
Luckily, ABC has already renewed Grey’s Anatomy for Season 23, so we know we’ll get the answers to these questions and more when the show returns this fall. Warning: There are spoilers ahead for Grey’s Anatomy‘s Season 22 finale.

What will Meredith and Nick’s wedding be like?
After Nick (Scott Speedman) narrowly survived an operation to repair his transplanted kidney after he was injured in the bridge collapse, Meredith (Ellen Pompeo) decided to take their relationship to the next level by proposing to him, and he accepted. Though she decided she won’t have a traditional wedding — she wouldn’t be Meredith if she did, after all — they are going to get hitched. With her first husband, Derek (Patrick Dempsey), they got “married” by Post-It note and only made it official when they had to at the courthouse. So how will Meredith and Nick say “I do”? Surely, it’ll be memorable somehow.

Is Jo going to quit medicine?
Another big question mark left open by the finale is whether Jo Wilson (Camilla Luddington) is going to quit practicing medicine altogether. She’d already expressed her frustrations with the OB residency, and the finale saw her skip out on her big test for that specialty. Now, it looks like she might not even return to her previous post as an attending in general surgery. So what’s next for Jo? Is she really going to step away from her hardwon career after all of these years?

Why is Link taking pills?
Jo’s not the only one who seems conflicted in that family. Link (Chris Carmack), after being overwhelmingly supportive of Jo’s right to whatever she wants to do with her life, took out a bottle of pills and downed one with a grimace that indicated something is seriously wrong. Is he secretly suffering from pain after his near-death experience in the explosion, or is he doing drugs for recreational reasons? Watch this space.

What will happen with Simone, Bryant, and Lucas?
After their drunken hook-up, Simone Griffith (Alexis Floyd) and Lucas Adams (Niko Terho) didn’t get much of a chance to talk before Wes Bryant (Trevor Jackson) walked in and interrupted. But what Lucas did say is that he doesn’t regret the encounter; still, Simone chose to take off with Wes, so what does that mean for all three of them? And given Simone’s fertility treatments of late, is it possible there’ll be a surprise pregnancy in store?

What’s next for Millin and Ndugu?
After witnessing all of the devastation of the bridge collapse, Winston Ndugu (Anthony Hill) and Jules Millin (Adelaide Kane) all but admitted that they had fallen in love with one another and didn’t want to keep it a secret anymore — good thing, too, because Ben Warren (Jason George) definitely clocked them sneaking out of the supply closet afterward. Ndugu has been married once before — well, twice, technically, if you count the backyard barbeque ceremony that Maggie’s (Kelly McCreary) father shut down as too “broke” — so could there be wedding bells in their future, too? Or maybe even more? Millin has been freezing her eggs, so maybe children are on her mind?

What’s next for Amelia and Toni?
It looked like Toni Wright (Jen Landon) might accept her ex’s offer to move to Seattle and reunite their family over Amelia Shepherd (Caterina Scorsone), but then she changed her mind and showed up at Amelia’s door to let her know. Unfortunately, Amelia had company at the time, which put an apparent end to that right then and there. Will this inspire Toni to leave Grey Sloan and Seattle and re-choose her ex-wife, or is there more to the story with Amelia’s visitor?

Is Kwan ever coming back?
Richard did not relent when Benson Kwan (Harry Shum Jr.) came asking for his job back after helping out with bridge collapse victims all day long. Though he was willing to look the other way for Miranda Bailey (Chandra Wilson), Blue will not be forgiven. Richard demanded his badge and walked away, despite a nice speech from Kwan about his value to the program and medicine in general. So is his firing for good, or will he be given a second chance like some of the other problematic interns past?

Is Miranda really going back to school?
Like Jo, Miranda was left with some questions about her future at the hospital in the finale — only, for her, it was about what she would need to do to become a Catherine Fox (Debbie Allen) and have “a seat at the table.” Ben accidentally revealed the potential answer — getting a master’s degree in public health administration — and said he’d be “all in” if that’s what she chooses to do next.

Will Owen and Teddy ever come back?
Owen and Teddy’s exit seemed like a forever goodbye to the show, but since they were both still alive at the end of it, there’s always a chance they could come back.

Could Cass and her husband take over their spots?
Cass Beckman (Sophia Bush) was on hand to help with traumas, including Nick’s surgery, during the finale, and it’s because she’s a trauma surgeon. Meanwhile, her husband, David (Wil Traval) is a cardiothoracic surgeon. With Owen and Teddy taking leave of the hospital, could Teddy’s former fling and her hubby slide in to fill their spots?

Who else will return to cameo?
Grey’s Anatomy‘s tradition of bringing back fan favorites who’ve left the show continued apace in Season 22, with the returns of Maggie Pierce, Jackson Avery (Jesse Williams), and Addison Montgomery (Kate Walsh). But there are still some we haven’t seen since their exits, including Izzie Stevens (Katherine Heigl), Cristina Yang (Sandra Oh), and Alex Karev (Justin Chambers). So who might suit back up in scrubs once again for Season 23? We’ll see!

Will this be the final season?
The question of when Grey’s Anatomy will inevitably end has been at the top of mind for fans for years, so it’s only natural to wonder if TV’s longest-running primetime medical drama will call it quits with this season or not.